TABLE 4.
Spectrum of activity for ADC compoundsa
| Speciesb | MIC (μg/ml)c |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| ADC111 | ADC112 | ADC113 | CIP | STR | DOX | RIF | VAN | TIG | |
| Francisella tularensis (SchuS4)* | ND | 0.097 | 0.195–0.34 | ND | 8 | ND | ND | ND | ND |
| Bacillus anthracis (Ames)* | 0.35 | 1.5 | 0.78 | 0.015 | ND | ND | ND | ND | ND |
| Yersinia pestis (KIM)* | ≤0.78 | 1.5 | 0.78–1.56 | ND | ND | 9 | ND | ND | ND |
| Escherichia coli (ATCC 25922) | 0.78 | 1.5 | 6.25–12.5 | 0.015 | ND | ND | ND | ND | ND |
| Staphylococcus aureus (NCTC 8325) | 1.56 | ≤1.5 | 3.12 | 0.15 | ND | ND | ≤0.06 | 1 | ND |
| Enterococcus faecalis (OG1RF, ATCC 47077) | 3.12 | ≤1.5 | 6.25 | 0.031 | ND | ND | ND | ND | ND |
| Salmonella Typhimurium (LT2) | 5 | ND | ND | ND | 2 | ND | ND | ND | ND |
| Staphylococcus aureus (MRSA, NRS54) | 6.25 | ≤1.5 | 6.25 | ND | ND | ND | ≤0.06 | 4 | ND |
| Clostridium difficile (CD196) | 6.25 | ≤1.5 | 6.25 | ND | ND | ND | ND | 1.5 | ND |
| Enterococcus faecium (VRE BM4147) | 12.5 | 6.25 | 6.25 | ND | ND | ND | ND | ND | 0.125 |
| Acinetobacter baumannii (AB17978) | 12.5 | 6.25 | 12.5 | 0.06 | ND | ND | ND | ND | ND |
| Pseudomonas aeruginosa (PAO1) | 25 | >50 | >50 | 0.031 | ND | ND | ND | ND | ND |
a
MICs were determined according to CLSI guidelines.
b
BSL3 agents are denoted by an asterisk and were tested at the NERCE/BEID facility in Boston, MA.
c
Abbreviations: CIP, ciprofloxacin; STR, streptomycin; DOX, doxycycline; RIF, rifampin; VAN, vancomycin; TIG, tigecycline; ND, not determined.