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Activity of test compounds against MDR pump mutant strainsa
| Strain | MIC (μg/ml)b |
|||||
|---|---|---|---|---|---|---|
| ADC111 | ADC112 | ADC113 | NFT | NFZ | ERY | |
| BW25113 | 1.25 | 2.5 | 12.5 | 12.5 | 6.25 | 200 |
| ΔtolC mutant | 0.4 | 0.67 | 1.25 | 3.125 | 3.12 | 1.56 |
| ΔacrB mutant | 1.25 | 2.5 | 3.12 | 6.25 | 3.12 | 1.56 |
MIC was determined by broth microdilution.
NFT, nitrofurantoin; NFZ, nitrofurazone; ERY, erythromycin.
