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. 2014 Mar;58(3):1410–1419. doi: 10.1128/AAC.02136-13

TABLE 6.

Activity of ADC111 against strains lacking and overexpressing activating enzymesa

Strain MIC (μg/ml)
ADC111 NFT
BW25113 2 12.5
BW25113ΔnfsAΔnfsB 16 50
BW25113ΔnfsA 4 12.5
BW25113ΔnfsB 2 12.5
nfsA++ 0.0156 0.025
nfsB++ 1 12.5
a

MIC was determined by broth microdilution.