TABLE 1.

Phenotypic and genotypic profiles of Enterobacteriaceae isolates used in the in vivo efficacy studies described here

Isolate	Known β-lactamase content (10, 13)	MIC (μg/ml)a
		DOR	ETP	CAZ	ATM	LEV
K. pneumoniae 454	None	0.03	0.012	0.25	≤0.25	≤0.06
K. pneumoniae 454 + NDM-1 plasmid	NDM-1	4	16	>128	2	0.125
E. coli 389	NDM-1, TEM-1, CTX-M-15	8	>32	>128	>256	32
E. coli 393	NDM-1, CTX-M-15, TEM-1, OXA-1, OXA-2	4	>32	>128	>256	32
K. pneumoniae 425	NDM-1, TEM-1, SHV-11, CTX-M-15, CMY-16, OXA-1, OXA-9, OXA-10	32	>32	>128	256	0.5
K. pneumoniae 450	NDM-1, SHV-11, SHV-28, TEM-1, CTX-M-15, OXA-1, OXA-9	>32	>32	>128	>256	16
K. pneumoniae 476	NDM-1	64	128	>128	64	>32
K. pneumoniae 477	NDM-1, SHV-2A, AmpC, DHA-1	64	128	>128	128b	>32
K. pneumoniae 478	NDM-1, CTX-M-15	>64	128	>128	>256	>32
E. cloacae 70	NDM-1	64	64	>128	128	0.5

^aDOR, doripenem; ETP, ertapenem; CAZ, ceftazidime; ATM, aztreonam; LEV, levofloxacin.

^bMedian value reported in the absence of a mode.