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Model depicting U21-mediated rerouting of class I MHC molecules to the lysosomal compartment. U21 (red) associates with and reroutes class I MHC molecules (blue) to a lysosomal compartment through association with a cellular protein, protein X (green), which contains lysosomal targeting information in its cytoplasmic tail. The association of protein X with the 4:2 U21-MHC I complex could occur in the ER (not depicted) or later in the secretory pathway (here shown in the TGN).
