FIG 5.

Kinetics of cell death rates during SHIV infection (the predictive model fits were used for these plots). (A) Indirect (solid lines) versus direct (dashed lines) death rates as functions of time. The indirect cell death rate encompasses the indirect terms affecting all target cells in the model (susceptible, modified, infected, and modified infected), while the direct effect rate accounts for the rate at which infected cells die from direct virus-induced apoptosis in the model. (B) Percentage of total cell death due to indirect effects (solid lines) and to direct virus-induced apoptosis of infected cells (dashed lines) during infection. (C) Percentage of total cell death in uninfected (bystander) cells (solid lines) versus infected (dashed) lines. (D) Rates of indirect (solid) versus direct (dashed) removal per cell for susceptible cells.