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Limited variation occurs within three HLA-B*57-03-restricted Gag and Nef epitopes during HIV infection of BLT Mice. HIV-1 isolates were amplified from the thymuses and spleens of BLT humanized mice at week 16 (isolates ES38-5 and ES38-9), week 8 (isolate ES8-43), and week 4 (isolates CP4-2B and CP6-2E), and Gag and Nef epitopes were analyzed. The red and blue boxes denote two distinct but overlapping Nef epitopes, HW9 (116 to 124) and YT9 (120 to 128), respectively.
