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(A) Relative Ki values of PIs for tested mutant PRs normalized to the wild-type protease at pH 5.6. (B) Relative resistance of corresponding recombinant mutant HIV-1 variants as determined by a cytopathic virus replication assay in the MT-2 T cell line. The arrows indicate that the relative resistance is equal to or higher than the presented value (compare the actual values in Table 1). EC50, 50% effective concentration.
