FIG 1.

Greater C. glabrata loads in the kidneys of mice during systemic infection. (A and B) Quantification of Candida colonies from liver (A) and kidneys (B) of wild-type (WT) and Dectin-2^−/− mice at days 3, 7, and 14 postinfection is shown. Wild-type and Dectin-2^−/− mice received 10⁷ CFU of C. glabrata per mouse intravenously. After 3, 7, and 14 days, organs were collected and serial dilutions were plated on Sabouraud solid medium. Results are means ± SEM (n = 10 to 14 mice per group from 3 independent experiments). Significance was determined with the Mann-Whitney U test. Statistically different groups are indicated as follows: *, P < 0.05; ***, P < 0.001. (C) Fungal burdens in the kidneys of wild-type and Dectin-2^−/− mice provided by Y. Iwakura. Wild-type or Dectin-2^−/− mice received 10⁷ CFU of C. glabrata per mouse intravenously. After 7 days, kidneys were collected and serial dilutions were plated on Sabouraud agar medium. Results are means ± SEM (n = 12 mice per group from two independent experiments). Significance was determined with the Mann-Whitney U test. **, P < 0.01.