TABLE 3.
QTL analysis of NOS2 SNPs that control anti-CSP antibody levels in the Principe populationa
| SNP no. | SNP reference | Gene region | Genotypes | Genotype nb (n = 1168) | Mean antibody level | Mean difference (95% CI) | Padj | Mean difference (95% CI) | Padj |
|---|---|---|---|---|---|---|---|---|---|
| 10 | rs3729508 | Intron 7* | GG/AG/AA | 680/405/61 | 1.645/1.764/1.780 | 0.098 (0.007–0.189) | 3.51E–02 | 0.033 (−0.050–0.116) | 0.4412 |
| 12 | rs6505469 | Intron 5 | AA/TA/TT | 679/411/60 | 1.635/1.768/1.817 | 0.112 (0.022–0.203) | 1.55E–02 | 0.040 (−0.043–0.124) | 0.3445 |
| 15 | rs3794767 | Intron 2 | CC/TC/TT | 713/377/53 | 1.634/1.791/1.755 | 0.118 (0.025–0.212) | 1.33E–02 | 0.040 (−0.046–0.126) | 0.3622 |
| 20 | rs8078340 | Promoter | GG/AG/AA | 603/447/96 | 1.760/1.661/1.433 | −0.146 (−0.23–0.063) | 6.25E–04 | −0.111 (−0.187–0.034) | 4.56E–03 |
| 21 | rs11080358 | Promoter | GG/AG/AA | 647/437/70 | 1.757/1.656/1.378 | −0.151 (−0.238–0.063) | 7.57E–04 | −0.106 (−0.186–0.026) | 9.34E–03 |
a
Analysis was performed using the log-additive model, and the results were adjusted for age and gender (first Padj column) and for age, gender, and asymptomatic status (second Padj column). Significant P values (Padj < 0.05) are highlighted in boldface. Mean difference refers to the mean antibody level difference. Introns denoted by asterisks are discussed in Table 2, footnote b.