FIG 10.
Dynamics of mouse body weight change after booster immunization followed by virulent challenge. Four-week-old SPF female BALB/c mice were immunized with MTase-defective VSVs intranasally at a dose of 5 × 106 PFU per mouse. At week 2 after primary immunization, mice were boosted intranasally with 5 × 106 PFU of the corresponding virus. At week 3 after booster immunization, mice were challenged with rVSV at a dose of 5 × 106 PFU per mouse. The body weight for each mouse was monitored every 3 days. The average body weight of four mice is shown.