FIG 6.

Specificities of AAV2 and -3 capsid binding to heparins. (A) Binding efficiencies of fluorescently labeled AAV2(R585A/R588A) and AAV3(R594A) vectors on heparin arrays displaying 13 different single synthetic heparin structures and low-molecular-weight natural heparin 14, each in replicates of 10. (B) Concentration-dependent binding of wild-type AAV2 and AAV3 to selected heparins. Heparins on arrays were present at increasing concentrations, 16 μM, 64 μM, 250 μM, and 1 mM, each in replicates of 10. The error bars represent standard deviations.