TABLE 1.
Level of replication and airway pathology following infection with sw/06 and AA wt and ca viruses in the respiratory tracts of ferrets
| Virus | Mean virus titera (±SE) in nasal turbinates on day postinfection: |
Mean virus titera (±SE) and pathology scoreb in lungs on day postinfection: |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |
3 |
5 |
7 |
|||||||||
| 1 | 3 | 5 | 7 | Mean virus titer (±SE) | Median (range) pathology severity score | Mean virus titer (±SE) | Median (range) pathology severity score | Mean virus titer (±SE) | Median (range) pathology severity score | Mean virus titer (±SE) | Median (range) pathology severity score | |
| sw/06 wt | 8.3 ± 0.3 | 7.4 ± 0.4 | 7.2 ± 0.2 | 3.4 ± 0.3 | 5.1 ± 0.2 | 3 (3–5) | 5.9 ± 0.1 | 4 (4–5) | 5.7 ± 1.0 | 4 (3–5) | 2.2 ± 0.4 | 5 (4–5) |
| sw/06 ca | 5.3 ± 0.2 | 5.0 ± 0.3 | 6.6 ± 0.6 | 4.4 ± 1.0 | ≤1.5 | 1 (1–2) | ≤1.5 | 0 (0) | ≤1.5 | 0 (0) | ≤1.5 | 0 (0) |
| AA wt | 5.5 ± 0.2 | 5.7 ± 0.2 | 4.8 ± 1.0 | ≤1.8 | 2.4 ± 0.2 | 4 (2–4) | 1.8 ± 0.3 | 1 (0–4) | ≤1.5 | 0 (0–2) | ≤1.5 | 1 (1) |
| AA ca | 4.4 ± 0.8 | 5.3 ± 0.2 | 5.5 ± 0.2 | 2.5 ± 0.4 | ≤1.5 | 0 (0–1) | ≤1.5 | 0 (0–1) | ≤1.5 | 0 (0) | ≤1.5 | 0 (0) |
a
Mean virus titers (expressed in log10 TCID50/g) from 3 ferrets in each group on each of the indicated days postinfection. Titers of 1.8 log10 TCID50/g and 1.5 log10 TCID50/g represent the lower limits of detection in the nasal turbinates and lungs, respectively.
b
Severity score of airway pathology was defined as follows: 0, within normal limits; 1, minimal inflammation; 2, mild to moderate inflammation; 3, moderate to severe inflammation; 4, severe multifocal to coalescing inflammation; 5, severe diffuse inflammation.