TABLE 3.
Level of replication of sw/06 ca reassortant and sw/06 wt viruses in the respiratory tract of ferretsa
| Virus | Source of: |
Nasal turbinates |
Lungs |
|||
|---|---|---|---|---|---|---|
| HA gene | NA gene | Virus titer (SEM) | P value vs wtb | Virus titer (SEM) | P value vs wtb | |
| sw/06 wt | sw/06 wt | sw/06 wt | 7.5 (0.1) | 5.9 (1.7) | ||
| sw/06 7:1(HA) ca | sw/06 wt | AA ca | 3.1 (0.8) | 0.0009 | 1.5 (0) | 0.0009 |
| sw/06 7:1(NA) ca | AA ca | sw/06 wt | 5.5 (0.3) | NS | 1.5 (0) | 0.0009 |
| sw/06 ca | sw/06 wt | sw/06 wt | 2.0 (0.2) | 0.0001 | 1.5 (0) | 0.0009 |
a
Viral titers represent the mean titer (expressed in log10 TCID50/g) from 3 ferrets at day 3 postinfection. A titer of 1.5 log10 TCID50/g represents the lower limit of detection in the nasal turbinates and lungs.
b
Two-way ANOVA. NS, not significant.