FIG 1.

Schematic diagrams of the genome structure of wild-type and recombinant viruses used in the present study. Line 1, Wild-type HSV-1(YK304) genome carrying a bacmid (BAC) in the intergenic region between UL3 and UL4. Line 2, domain carrying the UL49A, UL50 (vdUTPase) and UL51 open reading frames. Lines 3 to 7, 10, and 11, recombinant viruses with a mutation in the UL50 (vdUTPase) gene. Lines 8 and 9, recombinant viruses with a mutation in the UL51 gene. Lines 13 and 14, recombinant viruses with a mutation in the Us3 gene. Lines 15 and 16, recombinant viruses with mutations in the Us1 (ICP22) gene.