FIG 2.

Effect of mutations in vdUTPase or the kinase-dead mutation in Us3 on viral virulence in the CNS of mice following intracranial inoculation. (A to C) Sixteen (A and B) or seventeen (C) 3-week-old female ICR mice were infected intracranially with YK750 (ΔvdUTPase) (A), YK751 (vdUTPaseS187A) (A and C), YK752 (vdUTPaseΔ/SA-repair) (A and C), YK511 (Us3K220M) (B), YK513 (Us3K220M-repair) (B), YK753 (vdUTPaseS187D) (C), or YK754 (vdUTPaseS187D-repair) (C) and monitored for 14 days. P represents the statistical significance value according to the log-rank test. n.s., not significant.