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. 2014 Mar;88(5):2775–2785. doi: 10.1128/JVI.03300-13

FIG 4.

FIG 4

Effect of mutations in vdUTPase or the kinase-dead mutation in Us3 on viral pathogenicity in peripheral sites of mice following peripheral inoculation. (A) Fifteen 5-week-old female ICR mice pretreated with Depo-M were infected vaginally with YK511 (Us3K220M) or YK513 (Us3K220M-repair) and scored for vaginal disease every day for 14 days. Each data point is the mean ± the standard error of the scores. (B) Seventeen 5-week-old female ICR mice were ocularly infected with YK750 (ΔvdUTPase), YK751 (vdUTPaseS187A), or YK752 (vdUTPaseΔ/SA-repair) and scored for HSK every day for 14 days. Each data point is the mean ± the standard error of the scores. (C) Twenty 5-week-old female ICR mice pretreated with Depo-M were infected vaginally with YK750 (ΔvdUTPase), YK751 (vdUTPaseS187A), or YK752 (vdUTPaseΔ/SA-repair). The experiments were performed as described for panel A. Each data point is the mean ± the standard error of the scores. Asterisks represent the statistical significance value (*, P < 0.05) according to the two-tailed Student t test. n.s., not significant.