FIG 6.

Effect of phosphorylation of other viral proteins on viral replication in Vero cells. (A to D) Vero cells were infected at an MOI of 5 (left panels) or 0.01 (right panels) with wild-type HSV-1(F), YK755 (ICP22S5A/S22A/T162A/S167A), and YK756 (ICP22S5A/S22A/T162A/S167A-repair) (A and B) or wild-type HSV-1(F), YK757 (UL51T190A), and YK758 (UL51T190A-repair) (C and D). The total virus from the cell culture supernatants and infected cells was harvested at the indicated times and assayed on Vero cells. The data are representative of three independent experiments.