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. 2014 Mar;88(5):2775–2785. doi: 10.1128/JVI.03300-13

FIG 8.

FIG 8

Effect of the enzymatically inactive mutation in vdUTPase on viral pathogenicity in mice. (A) Sixteen 3-week-old female ICR mice were infected intracranially with YK759 (vdUTPaseD97A) and YK760 (vdUTPaseD97A-repair) and monitored for 14 days. (B) Seventeen 5-week-old female ICR mice were ocularly infected with YK750 (ΔvdUTPase), YK759 (vdUTPaseD97A), and YK760 (vdUTPaseD97A-repair) and scored for HSK as described for Fig. 4B. Each data point is the mean ± the standard error of the scores. (C) Seventeen 5-week-old female ICR mice pretreated with Depo-M were infected with YK750 (ΔvdUTPase), YK759 (vdUTPaseD97A), and YK760 (vdUTPaseD97A-repair), and the score of vaginal disease in mice was analyzed as described for Fig. 4C. Each data point is the mean ± the standard error of the scores. P represents the statistical significance value according to the log-rank test (A) or the two-tailed Student t test (B and C). n.s., not significant.