FIG 9.

Effect of the enzymatically inactive mutation in vdUTPase on viral replication in mice. (A) Fifteen 3-week-old female mice were infected intracranially with YK751 (vdUTPaseS187A) YK752 (vdUTPaseΔ/SA-repair), YK759 (vdUTPaseD97A), or YK760 (vdUTPaseD97A-repair). At 3 days postinfection, the brains of infected mice were harvested, and virus titers were assayed. Each data point is the virus titer in the brain of one mouse. The horizontal bars indicate the mean for each group. (B) The tear films of infected mice at 1 and 4 days postinfection in the experiment described in Fig. 8B were harvested, and virus titers were assayed. Each data point is the virus titer in the tear film of one mouse. The horizontal bars indicate the mean for each group. (C) The vaginal secretions of infected mice at 1 and 3 days postinfection in the experiment described in Fig. 8C were harvested, and virus titers were assayed. Each data point is the virus titer in the vaginal secretions of one mouse. The horizontal bars indicate the mean for each group. P represents the statistical significance value according to the two-tailed Student t test. n.s., not significant.