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Fusion regulatory residues are located very close to the central pocket microdomain of the morbillivirus F trimer. Shown is a close-up view of the central pocket microdomain. Residues highlighted in red (V447T and L372A) and yellow (L326A and P331A) were identified in this study and shown to increase fusion by destabilizing the prefusion F trimer. Residues highlighted in blue (S262 [66] and G264 [65]) were reported to influence cell-cell fusion and viral pathogenicity.
