FIG 8.

Model of apoptotic mimicry as a regulator of the local inflammatory response during viral infection. Early in infection, Ad virions increase local inflammatory responses through their direct interactions with αVβ3 integrins and CARs on tissue macrophages. Later during infection, as virally infected, dying host cells accumulate, the virally infected CPE corpses repress the local Ad virion-induced, macrophage-mediated proinflammatory responses through E1B 19K-dependent apoptotic mimicry. Adenovirus vector image from Dvorak, Integration and Application Network, University of Maryland Center for Environmental Science (http://ian.umces.edu/imagelibrary/displayimage-4798.html).