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. 2014 Mar;88(5):2600–2610. doi: 10.1128/JVI.02778-13

FIG 9.

FIG 9

Cellular immune responses induced by rMuVΔSHΔV vaccination in mice. (A) Memory T cell responses in mumps virus i.m.-immunized mice. BALB/c mice were i.m. immunized with PBS, rMuV, JL, rMuVΔSH, rMuVΔV, or rMuVΔSHΔV at 106 PFU and boosted at 22 days postvaccination with the same virus at 106 PFU. Splenocytes were extracted from mouse spleens and used for ELISPOT assay. Splenocytes were stimulated with MuV-infected Vero cell lysates or with mock-infected Vero cell lysates at 50 μg/ml. P values of <0.05 are shown. (B) Memory T cell responses in mumps virus i.n.-immunized mice. BALB/c mice were i.m. immunized with PBS, rMuV, JL, rMuVΔSH, rMuVΔV, or rMuVΔSHΔV at 106 PFU and boosted at 22 days postvaccination with the same virus at 106 PFU. Splenocytes were extracted from mouse spleens and used for ELISPOT assay. Splenocytes were stimulated with MuV-infected Vero cell lysates or with mock-infected Vero cell lysates at 50 μg/ml. P values of <0.05 are shown.