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. 2014 Mar;88(5):2442–2451. doi: 10.1128/JVI.02861-13

FIG 6.

FIG 6

Effect of SIRT1 inhibitor sirtinol on HBV replication. (A) Cell viability in HepG2.2.15 and HepG2-HBV1.1 cells after sirtinol treatment 48 h was examined by using MTS assay. (B and C) Sirtinol treatment inhibited HBV DNA level. HBV DNA in HepG2.2.15 and HepG2-HBV1.1 cells treated with different concentration of sirtinol for 48 h were extracted and subjected to real-time PCR (B) and Southern blot analysis (C). (D) The HBV 3.5-kb mRNA levels in HepG2.2.15 and HepG2-HBV1.1 cells treated with sirtinol were analyzed by using real-time PCR. *, P < 0.001.