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Correlation of the two in vitro PrP conversion systems. Conversion efficiencies are shown on a relative scale of the Gdn-HCl-based or the PMCA conversion system. A clear correlation exists between the Gdn-HCl and PMCA system for both scrapie types as well as cow BSE. Data for the scrapie-driven Gdn-HCl system came from Bossers et al. (13). Every measurement consisted of at least three independent conversion reactions.
