Figure 5.

Graphic representation of the confidence interval for interstitial and vessel area fractions of collagen type V as a function of the UIP histological patterns (A), for septal area fraction of type V collagen as a function of the control (non-UIP lung) and three different areas of UIP (B), and for interstitial and vessel area fractions of collagen type V as a function of patients' status (C). Kaplan-Meier survival curve for patients with UIP grouped by activity histological patterns. Significant difference is shown (log rank 437.45, p=0.005) between these groups (D). Note: (A) UIP histological patterns (activity). The three grades of fibrosis observed in UIP: 1 = minimal fibrosis, 2 = moderate fibrosis, and 3 = severe fibrosis presented a significant association with quantitation of type V collagen. (B) UIP histological areas. The three areas were observed in UIP: normal areas, alveolar collapse areas, and dense fibrosis areas with fibroblastic foci areas.