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. 2014 Mar 18;34(2):e00098. doi: 10.1042/BSR20130127

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© 2014 The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Licence (CC-BY)(http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.

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This model integrates the known PTM sites to refine our working model of DHCR24 membrane topology. As the focus of this work has been on the N-terminus, this hypothetical model does not attempt to encapsulate the membrane topology of the C-terminus, which is likely to snorkel in and out of the membrane similar to the N-terminus, and is therefore protected from trypsin digestion (Figure 2B, lanes 1–4 versus 6–9). Cofactor-binding sites marked: FAD (111–203), p53 (358–425), Mdm2 (203–215). Caspase cleavage sites (122–127, 383–387).