Table 5.

Comparison of SNP allele frequencies of the studied Caucasian sample with the data on Asian populations from databases and literature

Gene	SNP	Reference population	Database or reference	Data from a database or reference		Caucasiansa		P
				Frequencyb	n	Frequency	n
ER-α	9	Japanese	[83]	0.412	200	0.484	1,861	0.06
		Thai females	[84]	0.337	129	0.484	1,861	<0.01
	10	Korean males	[85]	0.39	219	0.449	1,861	0.11
		Korean females	[86]	0.415	248	0.449	1,861	0.35
		Japanese children	[87]	0.431	102	0.449	1,861	0.80
		Taiwanese	[88]	0.39	246	0.449	1,861	0.09
		Thai females	[89]	0.414	134	0.449	1,861	0.49
	11	SANGER 12 DNAs of Asian origin	dbSNP	0.36	12	0.257	1,857	0.49
	12	Japanese	[83]	0.483	200	0.218	1,859	<0.01
		Japanese females	[90]	0.481	306	0.218	1,859	<0.01
	13	Japanese	JSNP	0.34	744	0.098	1,863	<0.01
		TSC panel of unrelated Asians	TSC	0.27	32	0.098	1,863	0.01
	14	Japanese	JSNP	0.296	752	0.119	1,861	<0.01
	15	Japanese	JSNP	0.18	741	0.203	1,863	0.21
		Japanese	[83]	0.21	200	0.203	1,863	0.88
IL-6	16	Chinese	[31]	0.997	147	0.434	1,860	<0.01
		Chinese males	[31]	0.998	259	0.434	1,860	<0.01
		Japanese	[31]	1.000	388	0.434	1,860	<0.01
LEPR	20	TSC panel of unrelated Asians	dbSNP	0.13	42	0.353	1,860	<0.01
		Japanese	JSNP	0.15	748	0.353	1,860	<0.01
PTHR1	22	Japanese	JSNP	0.43	747	0.398	1,861	0.14
	23	Japanese	JSNP	0.43	748	0.374	1,863	0.01
	24	Japanese	JSNP	0.44	750	0.397	1,855	0.05
	25	Japanese	JSNP	0.43	746	0.380	1,851	0.02
TGF-ß1	26	TSC panel of unrelated Asians	dbSNP	0.47	36	0.311	1,840	0.06
TNFR2	31	Japanese	[91]	0.113	265	0.198	1,842	<0.01
		Thai	[92]	0.127	201	0.198	1,842	0.02
UCP3	33	Asiansc	[73]	0.00	11	0.000	295	10.00
	35	Japanese	JSNP	0.45	750	0.447	1,863	0.92
	36	Asiansc	[73]	0.04	11	0.000	295	0.54
VDR	37	Japanese	JSNP	0.23	750	0.281	1,861	0.01
	38	Japanese	[93]	0.37	195	0.373	1,861	0.99
	40	SANGER 12 DNAs of Asian origin	dbSNP	0.41	12	0.419	1,860	0.77
		Chinese females (Han nationality)	[94]	0.043	162	0.419	1,860	<0.01
		Taiwanese	[95]	0.083	90	0.419	1,860	<0.01
		Japanese	[93]	0.13	195	0.419	1,860	0.02
		Koreans	[96]	0.055	211	0.419	1,860	<0.01
		Thai females	[97]	0.107	84	0.419	1,860	0.01
	41	Chinese (Han nationality)	[98]	0.05	223	0.408	1,859	<0.01
		Japanese females	[99]	0.135	119	0.408	1,859	<0.01
		Koreans	[96]	0.055	120	0.408	1,859	<0.01

For gene abbreviations and SNP designations see Table 1. ^a Present study. ^b Frequency of the allele corresponding to a minor allele in the present study. ^c Asians with unidentified ethnic background.