Figure 2.
Prophylactic efficacy of HMAb 1F4 in DENV1-inoculated AG129 mice.
A, B Mice were administered 20 μg of HMAb 1F4 or 50 μg IgG1 isotype control 24 h prior to a sub-lethal dose of 5 × 106 pfu of DENV1 Western Pacific 74. Serum viremia (A) and bone marrow viral load (B) were determined 3 days post-infection by qRT-PCR. One representative experiment of two is shown, with n = 4 mice per group. DENV1 limit of detection is indicated by the dashed line. *P = 0.0209 compared to IgG1 control, as determined using a 2-tailed Wilcoxon Rank Sum test.