Figure 7.

Efficacy studies in vivo.

1. Efficacy of 5 PBTZ candidates in a mouse model of chronic TB compared with INH (25 mg/kg), BTZ043 and untreated controls (NT). All BTZs were administered at 50 mg/kg of body weight per day. Red and black columns correspond to the bacterial burden in the lungs and spleens, respectively, at day 0 (D0) when treatment initiated, or day 28 (D28) when treatment finished. Bars represent the mean ± s.d. of CFUs from 5 mice per group. Significance in difference relative to BTZ043 were calculated using Student's t-test. *P < 0.05; **P < 0.005.
2. Dose escalation study of PBTZ169 in the same model. 5 mice per group were treated with various drugs at the doses indicated (mg/kg). Colors, bars and statistics are as in (A).