Figure 9.

Efficacy of PBTZ169-based combination treatment in mice. The bactericidal effects of PBTZ, BDQ (both 25 mg/kg) and PZA (150 mg/kg) alone and in combination were compared in the lung (A) and in the spleen (B) with a standard regimen of RIF, INH and PZA (RHZ) and untreated controls (NT) in the murine model of chronic TB. The combination of PBTZ169 and BDQ plus PZA was significantly more effective than the standard treatment in reducing the number of CFU in both organs after 1 and 2 months of treatment (Supplementary Table 6). The lung CFU count of PBTZ-BDQ-PZA (*) was below the limit of detection used after 4 weeks of treatment (<200 CFU).