Table 1.
Correlation between MIC of selected PBTZ and logP
| Compound number | Alkyl substitute | MIC M. tuberculosis (ng/ml) | logP* |
|---|---|---|---|
| 10926013 | Methyl | 250 | 1.31 |
| 10926021 | Ethyl | 62 | 1.64 |
| 10926027 | Propyl | 3.7 | 2.11 |
| 10926172 | Butyl | 1.9 | 2.51 |
| 11026100 | Isobutyl | 1.9 | 2.51 |
| 11026142 | 1-Ethylpropyl | 0.37 | 2.99 |
| 11026128 | 1-sec-Butyl | 0.37 | 2.52 |
| 11026129, PBTZ129 | 2-Cyclohexylethyl | 0.19 | 3.52 |
| 11026131 | 1-Methylbutyl | 0.19 | 3.11 |
| 11026134, PBTZ134 | Heptyl | 0.19 | 3.30 |
| 11026137, PBTZ137 | 4-Phenoxybutyl | 1.5 | 3.35 |
| 11026139, PBTZ139 | 4-Phenylbutyl | 0.37 | 4.05 |
| 10926168 | Cyclohexyl | 0.75 | 3.09 |
| 10926169, PBTZ169 | Cyclohexylmethyl | ≤0.19 | 3.20 |
*
Calculated using Hyperchem 7.5 (Hypercube Inc., http://www.hyper.com).