Table 3. Functional annotation clustering of differentially methylated genes found in multiple versus solitary tumors based on DAVID analysis.

Category	Term	Count	P value	Genes
GOTERM_BP_FAT	GO:0006928∼cell motion	12	1.66821E-05	FGF19, SMO, RET, GDF7, ARHGEF7, UNC5A, ERBB2, GBX2, DPYSL5, KITLG, CXCL12, RUNX3
GOTERM_MF_FAT	GO:0003700∼transcription factor activity	14	0.000934574	IRX3, THRB, SOX14, SOX5, ZNF232, SOX8, GLI3, DLX5, GBX2, HIF3A, TFAP2A, ALX4, RUNX3, FOXE3
GOTERM_BP_FAT	GO:0016477∼cell migration	7	0.002226607	FGF19, SMO, RET, ARHGEF7, GBX2, KITLG, CXCL12
KEGG_PATHWAY	hsa05200:Pathways in cancer	8	0.002975368	FGF19, SMO, RET, ERBB2, WNT9B, KITLG, GLI3, DAPK1
GOTERM_BP_FAT	GO:0048870∼cell motility	7	0.003771569	FGF19, SMO, RET, ARHGEF7, GBX2, KITLG, CXCL12
GOTERM_BP_FAT	GO:0042127∼regulation of cell proliferation	11	0.004572205	SMO, HRH3, CCKBR, ERBB2, DLX5, KITLG, PDGFC, IGFBP3, GLI3, FOXE3, RUNX3
SP_PIR_KEYWORDS	transcription regulation	17	0.009600471	IRX3, MTERF, ZNF264, THRB, SOX14, SOX5, ZNF232, PRDM16, SOX8, GLI3, ZNF681, GBX2, HIF3A, TFAP2A, ALX4, RUNX3, FOXE3