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. 2014 Mar 18;11(3):e1001618. doi: 10.1371/journal.pmed.1001618

Table 3. Associations between the weighted allelic score for 32 SNPs and body mass index/fat mass index and activity measures.

Outcome Per Allele Effects Per Allele Effects (Adjusted for Activitya)
N Z-Score Value Coefficient (95% CI)b Difference in Adiposity or Activity, Raw Units (95% CI)b p-Value Z-Score Value Coefficient (95% CI)b Difference in Adiposity or Activity, Raw Units (95% CI)b p-Value
BMI (kg/m2) 4,296 0.04 (0.04, 0.05) 0.14 (0.12, 0.17) 5.5×10−29 0.04 (0.03, 0.05) 0.14 (0.11, 0.16) 4.2×10−28
FMI (kg/m2) 4,244 0.04 (0.03, 0.05) 0.11 (0.09, 0.13) 2.3×10−25 0.04 (0.03, 0.05) 0.10 (0.08, 0.12) 2.3×10−24
Total physical activity (counts/min) 4,296 −0.01 (0.00, −0.02) −1.4 (−2.8, −0.03) 0.05
Moderate-to-vigorous activity (min/d)c 4,296 −0.01 (−0.02, 0.00) −0.12 (−0.24, −0.00) 0.05
Sedentary time (min/d) 4,296 0.01 (0.00, 0.02) 0.57 (0.06, 1.1) 0.03

Regression results were adjusted for age. Per (average BMI-increasing) allele effects were obtained by linear regression for all of these continuous outcome variables.

a

Activity variables were total physical activity, moderate-to-vigorous and minutes of sedentary time.

b

Coefficients are displayed as sex-specific z-scores for both measures of adiposity and activity levels and have also been rescaled to give more meaningful outcomes relating to the raw units of these variables. The raw-unit difference was computed by multiplying the z-score value by the SD of the variable, taken from Table 1.

c

Moderate-to-vigorous activity was log transformed for analysis.