Table 3. Associations between the weighted allelic score for 32 SNPs and body mass index/fat mass index and activity measures.
| Outcome | Per Allele Effects | Per Allele Effects (Adjusted for Activitya) | |||||
| N | Z-Score Value Coefficient (95% CI)b | Difference in Adiposity or Activity, Raw Units (95% CI)b | p-Value | Z-Score Value Coefficient (95% CI)b | Difference in Adiposity or Activity, Raw Units (95% CI)b | p-Value | |
| BMI (kg/m2) | 4,296 | 0.04 (0.04, 0.05) | 0.14 (0.12, 0.17) | 5.5×10−29 | 0.04 (0.03, 0.05) | 0.14 (0.11, 0.16) | 4.2×10−28 |
| FMI (kg/m2) | 4,244 | 0.04 (0.03, 0.05) | 0.11 (0.09, 0.13) | 2.3×10−25 | 0.04 (0.03, 0.05) | 0.10 (0.08, 0.12) | 2.3×10−24 |
| Total physical activity (counts/min) | 4,296 | −0.01 (0.00, −0.02) | −1.4 (−2.8, −0.03) | 0.05 | |||
| Moderate-to-vigorous activity (min/d)c | 4,296 | −0.01 (−0.02, 0.00) | −0.12 (−0.24, −0.00) | 0.05 | |||
| Sedentary time (min/d) | 4,296 | 0.01 (0.00, 0.02) | 0.57 (0.06, 1.1) | 0.03 | |||
Regression results were adjusted for age. Per (average BMI-increasing) allele effects were obtained by linear regression for all of these continuous outcome variables.
a
Activity variables were total physical activity, moderate-to-vigorous and minutes of sedentary time.
b
Coefficients are displayed as sex-specific z-scores for both measures of adiposity and activity levels and have also been rescaled to give more meaningful outcomes relating to the raw units of these variables. The raw-unit difference was computed by multiplying the z-score value by the SD of the variable, taken from Table 1.
c
Moderate-to-vigorous activity was log transformed for analysis.