Table 3. Pooled Analysis on Association between the C509T polymorphism and the RP risk.
C509T | |||||||
Genetic Model | Number of study | Sample size | Analysis Model | I2 | Test of Association(95%CI) | ||
case | control | P | OR | ||||
Dominant model | 7 | 337 | 817 | F | 0 | 0.16 | 0.82 [0.62, 1.08] |
Recessive model | 5 | 171 | 600 | F | 5 | 0.21 | 0.74 [0.47, 1.18] |
CT vs. CC | 5 | 169 | 499 | F | 0 | 0.36 | 0.84 [0.58, 1.22] |
TT vs. CC | 5 | 113 | 344 | F | 0 | 0.10 | 0.63 [0.36, 1.08] |
Ethnicity | |||||||
Asian | |||||||
Dominant model | 4 | 176 | 465 | F | 0 | 0.68 | 0.92 [0.61, 1.38] |
Recessive model | 3 | 113 | 358 | F | 48 | 0.25 | 0.75 [0.46, 1.23] |
CT vs. CC | 3 | 84 | 251 | F | 0 | 0.92 | 1.00 [0.59, 1.70] |
TT vs. CC | 3 | 59 | 193 | F | 11 | 0.55 | 0.70 [0.39, 1.28] |
Caucasian | |||||||
Dominant model | 3 | 161 | 352 | F | 0 | 0.12 | 0.73 [0.49, 1.09] |
Recessive model | 2 | 58 | 242 | F | 0 | 0.60 | 0.69 [0.18, 2.71] |
CT vs. CC | 2 | 84 | 251 | F | 0 | 0.99 | 1.00 [0.59, 1.70] |
TT vs. CC | 2 | 54 | 151 | F | 0 | 0.19 | 0.39 [0.10, 1.57] |
Dominant model: CT+TT vs. CC; Recessive model: TT vs. CC+CT; Additive model: T vs. C; R, Random-effects model; F, fixed-effects model;