Table 1. Model parameters.

Parameter	Reaction definition	Value	Reference
kv·	V and Vmij formation	3.0 vesicle−1 h−1	fitting
mv	V and Vmij, pcf, pcfmij degradation	0.058 h−1	[64]
kout	Wild-type RNA (R) production by vesicles V	1.177 h−1	fitting
	Mutant RNA (Rm ij) production by vesicles Vmij	1.177 h−1	fitting
mr	R and Rm ij degradation	0.5 h−1	[65]
kt	Wild-type and mutant polyprotein translation	0.1 h−1	[52]
kc	Wild-type polyprotein processing	1.0 h−1	[66]
kp	pcf, pcfmij formation	0.75 molecule−1 h−1	fitting
kcf	Cellular factor (cf) synthesis	5.0 h−1	fitting
mp	Nonstructural proteins (p, pm ij) degradation	1.0 h−1	fitting
mpolyp	Mutant (polypmij), wild-type (polyp) polyprotein degradation,	0.3 h−1	fitting
	Complexes (polypi, polypmiij, polypi *, polypmiij *) degradation	0.3 h−1	fitting
kout_v_vm	Rmij production by vesicles (V) containing wild-type viral RNA	2·10−4 h−1	[5]
kout_vm_v	R production by vesicles (Vmij) containing mutant viral RNA	2·10−4 h−1	[5]
ki	polypi formation	0.12 molecule−1 h−1	[59]
ki_rev	polypi dissociation	84 h−1 *	[59]
		15.3·104 h−1 **	[59]
		14.8·104 h−1 ***	[59]
ki2	Covalent polyprotein/inhibitor complex (polypi *, polypmiij *) formation	0 h−1 *	[59]
		56.52 h−1 **	[59]
		59.05 h−1 ***	[59]
ki_rev2	polypi, polypmiij formation from covalent (polypi *, polypmiij *) complex	0 h−1 *	[59]
		0.2952 h−1 **	[59]
		0.108 h−1 ***	[59]
mcf	cf degradation	1.0 h−1	fitting

*for the polyprotein(wild-type)/BILN-2061 complex.

**for the polyprotein(wild-type)/VX-950 complex.

***for the polyprotein(wild-type)/SCH-503034 complex.