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. 2014 Mar 18;9(3):e91502. doi: 10.1371/journal.pone.0091502

Table 4. Stationary concentration of the viral RNA calculated by the model.

HCV replicon Rate constant for polyprotein processing kcmij (h-1) Minus-strand RNA (molecules per cell) Plus-strand RNA (molecules per cell) Time to reach steady state (days)
WT 1 70 670 5
A156T 0.42 0.018 0.17 10
D168V 0.5 0.025 0.23 10
A156S 0.75 0.12 1.15 40
T54A 0.95 0.32 3.06 60
R155Q 0.95 0.32 3.06 60