Table 4. Stationary concentration of the viral RNA calculated by the model.
HCV replicon | Rate constant for polyprotein processing kcmij (h-1) | Minus-strand RNA (molecules per cell) | Plus-strand RNA (molecules per cell) | Time to reach steady state (days) |
WT | 1 | 70 | 670 | 5 |
A156T | 0.42 | 0.018 | 0.17 | 10 |
D168V | 0.5 | 0.025 | 0.23 | 10 |
A156S | 0.75 | 0.12 | 1.15 | 40 |
T54A | 0.95 | 0.32 | 3.06 | 60 |
R155Q | 0.95 | 0.32 | 3.06 | 60 |