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. 2014 Mar 18;9(3):e91807. doi: 10.1371/journal.pone.0091807

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© 2014 Maguire et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Auditory brainstem response threshold was elevated across all frequencies in homozygous Slc25a21^{tm1a(KOMP)Wtsi} mice aged 1, 2, 3 and 6 months respectively. Mean ABR thresholds (± SD) are shown for wild-type (green symbols), heterozygote (blue symbols) and homozygote (red symbols) Slc25a21^{tm1a(KOMP)Wtsi} mice (A–D). The click-evoked ABR thresholds (mean ± SD) plotted as a function of age (months) demonstrated a progressive deterioration in Slc25a21^{tm1a(KOMP)Wtsi} mice (E); an observation clearly demonstrated by plotting the mean click-evoked ABR threshold elevation of mutants above wild-types as a function of age (months) (F).