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. 2014 Mar 18;9(3):e91743. doi: 10.1371/journal.pone.0091743

Figure 1. Motifs topologies overrepresented in mammalian signaling networks.

Figure 1

In all of the motifs, “I” is the input source that activates signals across the networks; “A, B” are intermediate components; and “X, Y” are downstream effectors. LM: linear motif; NFB: negative feedback; PFB: positive feedback; PNFB: positive-negative feedback; NFF: negative feed-forward; PFF: positive feed-forward; PNFF: positive-negative feed-forward; CB: coherent bifan; IB: incoherent bifan; PCB: partially coherent bifan; iNFB: isolated negative feedback; iPFB: isolated positive feedback.