Table 2. GltPh residues involved in the coordination of the ligands and their equivalents in EAAT1, EAAT2 and EAAT3.
GltPh | Y89 | T92 | S93 | Q242 | R276 | S277 | S278 | G306 | T308 |
EAAT1 | Y127 | T130 | T131 | H328 | S363 | S364 | S365 | G394 | T396 |
EAAT2 | Y124 | T127 | T128 | H326 | A361 | S362 | S363 | G392 | T394 |
EAAT3 | Y98 | T101 | T102 | H296 | S331 | S332 | S333 | G362 | T364 |
GltPh | N310 | D312 | T314 | Y317 | Q318 | S349 | I350 | T352 | G354 |
EAAT1 | N398 | D400 | T402 | Y405 | E406 | S437 | I438 | A440 | G442 |
EAAT2 | N396 | D398 | T400 | Y403 | E404 | S435 | I436 | A438 | S440 |
EAAT3 | N366 | D368 | T370 | Y373 | E374 | S405 | I406 | A408 | G410 |
GltPh | V355 | G359 | D390 | D394 | M395 | R397 | T398 | N401 | D405 |
EAAT1 | I443 | G447 | D472 | D476 | R477 | R479 | T480 | N483 | D487 |
EAAT2 | I441 | G445 | D470 | D474 | R475 | R477 | T478 | N481 | D485 |
EAAT3 | V411 | G415 | D440 | D444 | R445 | R447 | T448 | N451 | D455 |
Residues from the mutagenesis experiments in Table 1 are also included in the table. Those residues that are not conserved between GltPh and EAATs are indicated with boldface. Human sequences are used for EAAT3.