Table 3. Determinants of insulin sensitivity in multivariate regression models in TULIP.

	Insulin sensitivityOGTT			Insulin sensitivityClamp
Covariates	Estimate±SE	F-value	p	Estimate±SE	F-value	p
Models 1
Female sex	0.04±0.03	1.3	0.25	0.003±0.04	0.0	0.93
Age	−0.29±0.11	6.8	0.01	−0.31±0.13	6.0	0.015
Adiponectin levels	0.38±0.07	30.4	<0.0001	0.52±0.08	43.5	<0.0001
Fetuin-A levels	−0.85±0.16	28.4	<0.0001	−0.72±0.18	16.1	<0.0001
Models 2
Female sex	−0.01±0.04	0.24	0.63	−0.03±0.04	0.5	0.48
Age	−0.17±0.10	2.6	0.11	−0.17±0.11	2.3	0.13
Adiponectin levels	0.24±0.06	14.2	0.0002	0.36±0.07	25.3	<0.0001
Fetuin-A levels	−0.70±0.14	23.8	<0.0001	−0.59±0.16	14.4	0.0002
BMI	−−0.54±0.31	3.0	0.08	−1.05±0.33	10.1	0.002
Waist circumference	−1.16±0.43	7.4	0.007	−0.68±0.45	2.3	0.13
Models 3 *
Female sex	−0.004±0.04	0.01	0.91	−0.03±0.04	0.6	0.44
Age	−0.09±0.10	0.7	0.39	−0.007±0.11	0.004	0.95
Adiponectin levels	0.17±0.07	6.5	0.01	0.27±0.07	14.2	0.0002
Fetuin-A levels	−0.69±0.15	22.9	<0.0001	−0.48±0.16	9.2	0.003
BMI	−0.91±0.34	7.2	0.008	−0.91±0.36	6.4	0.01
Waist circumference	0.13±0.43	0.07	0.79	−0.06±0.50	0.02	0.90
Liver fat content	−0.20±0.03	52.0	<0.0001	−0.20±0.03	48.2	<0.0001

*N = 291 for insulin sensitivity_OGTT and N = 203 for insulin sensitivity_Clamp.