Figure 1. Elevated and overlapping levels of markers of inflammation and tissue damage in febrile neutropenic hematology patients with or without infection.

Serum levels of (A) procalcitonin, (B) C-reactive protein, and plasma levels of (C) citrulline in patients with (n = 13) and without proven infection (n = 29). Each symbol denotes one patient and the horizontal line indicates the median. Dashed line shows upper limit of normal reference interval for procalcitonin and CRP. Normal level of citrulline in healthy individuals is >20 μmol/L [21], [41]. Statistical significance was determined by the Mann-Whitney test.