Table 3. Contribution of biochemical and physical variables to a model predicting infection in systemically inflamed neutropenic hematology patients.

Variable			Patient group with highest level of analyte	Included in model
Name	Short name	Impor-tancea		55-variable	40-variable
S-Procalcitonin	Procalc	2.5	Infectedb	X	X
S-Urea	Urea	2.3	Non-infectedb	X	X
B-White blood cell count	WBC	2.3	Infected	X	X
S-Interleukin-10	IL-10	2.2	Infected	X	X
S-Bilirubin	Bil	2.0	Infected	X	X
S-Interleukin-8	IL-8	1.9	Infected	X	X
P-Factor XII (Hageman factor)	XII	1.9	Non-infected	X	X
B-Erythrocyte volume fraction	EVF	1.8	Non-infected	X	X
S-Bilirubin (conjugated)	BilC	1.8	Infected	X	X
B-Hemoglobin	Hb	1.7	Non-infected	X	X
Current smoker	Smok	1.7	Non-infected	X	X
S-Cortisol	Cort	1.7	Infected	X	X
B-Lymphocyte count	Lymph	1.6	Non-infected	X
P-Plasminogen activator inhibitor-1	PAI	1.6	Infected	X	X
P-von Willebrand factor	vWF	1.6	Infected	X	X
S-High mobility group box protein-1	HMGB	1.6	Non-infected	X	X
S-Prohepcidin	Prohep	1.5	Infected	X	X
S-Low-density lipoprotein	LDL	1.5	Non-infected	X	X
B-Neutrophil count	Neu	1.5	Non-infected	X
S-C4b-binding protein (β-chain-containing isoform)	C4BPb	1.4	Non-infected	X	X
S-Cystatin C	CysC	1.4	Infected	X	X
P-Glucose	Glu	1.4	Infected	X
P-Protein S	Prot S	1.4	Non-infected	X	X
Cyclosporin A treatment	CyA	1.3	Infected	X	X
S-Hepcidin	Hepc	1.3	Infected	X	X
B-Mean corpuscular hemoglobin concentration	MCHC	1.3	Infected	X	X
B-Eosinophil count	Eos	1.3	Non-infected	X
S-Alpha fetoprotein	AFP	1.3	Infected	X	X
S-Lactate dehydrogenase	LD	1.3	Non-infected	X
Blood pressure (diastolic)	BPd	1.3	Non-infected	X	X
S-Cholesterol	Chol	1.3	Non-infected	X	X
B-Reticulocyte count	Ret	1.3	Non-infected	X	X
S-Immunoglobulin E	IgE	1.3	Non-infected	X
Peripheral vein sampling	Per	1.2	Non-infected	X	X
Port-a-catheter	PAC	1.2	Infected	X	X
S-Interleukin-1	IL-1	1.2	Infected	X	X
B-Mean corpuscular volume	MCV	1.2	Non-infected	X	X
B-International Normalized Ratio ( =  prothrombin time)	INR	1.2	Infected	X	X
P-Factor X	X	1.2	Non-infected	X	X
B-Monocyte count	Mono	1.2	Non-infected	X
S-C-reactive protein	CRP	1.2	Infected	X	X
S-Ferritin	Ferri	1.1	Infected	X
S-Potassium	K	1.1	Infected	X
S-Hemopexin	Hpx	1.1	Non-infected	X
S-Troponin T	TropT	1.1	Infected	X	X
B-Hemoglobin A	HbA	1.1	Non-infected	X
S-Transferrin	Trans	1.1	Non-infected	X	X
S-Immunoglobulin M	IgM	1.0	Infected	X
S-Sodium	Na	1.0	Non-infected	X	X
B-Basophil count	Bas	1.0	Non-infected	X
B-Erythrocyte particle concentration	EPC	1.0	Non-infected	X	X
S-Orosomucoid	Oro	1.0	Non-infected	X
P-Activated partial thromboplastin time	APTT	1.0	Infected	X	X
S-Thyroid stimulatory hormone	TSH	1.0	Non-infected	X
S-Total iron binding capacity	TIBC	1.0	Non-infected	X	X
Allogeneic transplant recipient	Allo	0.97
P-Coagulation factor II (prothrombin)	II	0.96
Erythrocyte sedimentation rate	SR	0.91
S-High density lipoprotein	HDL	0.88
S-Chloride	Cl	0.85
S-Amylase, pancreatic	AmyP	0.83
S-Alanine aminotransferase	ALT	0.81
S-Immunoglobulin G	IgG	0.79
S-Albumin	Alb	0.79
B-Platelet count	PC	0.78
P-Coagulation factor VII	VII	0.72
S-Testosterone	Test	0.71
S-Interleukin-6	IL-6	0.70
S-Triiodothyronine	T3	0.69
S-Creatinine	Crea	0.68
S-Leptin	Lep	0.68
S-Myoglobin	Myo	0.67
Blood pressure, systolic	BPs	0.67
S-Tetraiodothyronine	T4	0.67
S-Tumor necrosis factor	TNF	0.65
S-Estrogen	Est	0.65
S-Protein	Prot	0.64
Patient fasting prior to blood sampling	Fast	0.63
S-Creatine kinase, muscle brain	CKM	0.63
S-Transferrin saturation	TransS	0.60
P-Factor XI	XI	0.60
S-Triglycerides	TG	0.60
S-α2-macroglobulin	a2M	0.59
S-Aspartate aminotransferase	AST	0.59
S-Soluble transferrin receptor	TfR	0.57
Body length	Leng	0.56
P-Protein C	ProtC	0.55
Cytarabine treatment, current	Cytar	0.53
S-Iron	Fe	0.52
No of fever days prior to inclusion	Fday	0.52
S-Urate	Urate	0.52
S-Insulin growth factor-1	IGF-1	0.51
Peripheral vein catheter	PVC	0.50
S-Ceruloplasmin	Cer	0.49
Body weight	Wt	0.48
S-Phosphate	P	0.48
S-Haptoglobin	Hap	0.47
P-Factor VIII	VIII	0.47
S-Immunoglobulin A	IgA	0.47
Autologous transplant recipient	Auto	0.47
S-Alkaline phosphatase	ALP	0.46
Heart rate	HR	0.45
B-Erythrocyte mean corpuscular hemoglobin	MCH	0.44
P-Coagulation factor V	V	0.39
S-Tetratiodothyronine, free	T4f	0.39
S-Adiponectin	Adip	0.38
S-Prostate specific antigen, free	PSAf	0.37
S-γ-Glutamyl transferase	gGT	0.32
P-Dimerized plasmin fragment D	Dim	0.32
S-Thyroxin-binding globulin	TBG	0.32
Age	Age	0.28
P-Erythropoietin	EPO	0.27
Central venous catheter	CVC	0.27
S-Interferon-γ	IFNg	0.27
S-Triiodothyronine, free	T3f	0.26
Hypogammaglobulinemia	Hypog	0.26
S-Calcium	Ca	0.25
S-Amyloid A	SAA	0.24
S-Fibrinogen	Fibrino	0.24
Temperature	Temp	0.22
Presence of chills	Chills	0.20
Peripheral oxygen saturation	POX	0.19
S-Interleukin-17	IL-17	0.19
S-C4b-binding protein-α chain	C4BPa	0.18
S-Complement factor 3	C3	0.17
Sex	Sex	0.16
S-Lactoferrin	Lact	0.16
P-anti-thrombin	a-thrombin	0.14
S-Amylase, total	AmyT	0.14
S-Creatine kinase	CK	0.14
S-Magnesium	Mg	0.14
S-Prostate-specific antigen	PSA	0.093
S-Total complement complex	TCC	0.076
Corticosteroid therapy	Co	0.066
P-Renin	Ren	0.056
S-α1-antitrypsin	AT	0.032
S-Complement factor 4	C4	0.025
S-NT pro-brain natriuretic peptide	pBNP	0.015
P-Factor IX	IX	0.0051

Abbreviations: S  =  serum, P  =  blood plasma, B  =  blood.

^aThe relative importance of each variable to the 139-variable model was determined using the “Variable importance” module in the SIMCA software.

^bPatients were classified as infected or non-infected by an independent infectious disease specialist blinded to the results of the biochemical analyses