Table 2.
Baseline clinical variables tested as potential covariables with regard to nighttime systolic and diastolic blood pressure response to atenolol and hydrochlorothiazide in white and black Pharmacogenomic Evaluation of Antihypertensive Responses study participants randomized to initial treatment with atenolol or hydrochlorothiazide
| Characteristic | Male (n = 212) | Female (n = 273) | P value male vs. female | White (n = 281) | Black (n = 204) | P value white vs. black |
|---|---|---|---|---|---|---|
| Any exercise, no. (%) | 134 (64.4) | 186 (67.1) | 0.53 | 182 (64.8) | 138 (67.6) | 0.51 |
| Any drink, no. (%) | 156 (75.0) | 182 (65.7) | 0.03 | 224 (79.7) | 114 (55.9) | <0.01 |
| Any cigarettes, no. (%) | 93 (44.9) | 86 (31.2) | <0.01 | 113 (40.5) | 66 (32.4) | 0.07 |
| Serum creatinine, mg/dl | 1.01±0.01 | 0.82±0.01 | <0.01 | 0.91±0.01 | 0.88±0.01 | 0.10 |
| eGFR, ml/min | 92.2±1.6 | 91.5±1.3 | 0.74 | 85.9±1.2 | 100.1±1.6 | <0.01 |
| Sodium, mEq/L | 139.8±0.2 | 140.1±0.1 | 0.19 | 140.3±0.1 | 139.5±0.2 | <0.01 |
| Potassium, mEq/L | 4.32±0.03 | 4.11±0.03 | <0.01 | 4.30±0.02 | 4.07±0.03 | <0.01 |
| Magnesium, mg/dl | 2.12±0.02 | 2.00±0.02 | <0.01 | 2.19±0.01 | 1.86±0.02 | <0.01 |
| Serum uric acid, mg/dl | 6.32±0.09 | 4.91±0.07 | <0.01 | 5.57±0.08 | 5.43±0.10 | 0.28 |
| Hemoglobin, g/L | 15.1±0.1 | 13.2±0.1 | <0.01 | 14.6±0.1 | 13.3±0.1 | <0.01 |
| WBC, 1,000/cc3 | 5.8±3.1 | 5.8 ± .38 | 0.87 | 6.6 ± .34 | 4.7 ± .47 | <0.01 |
| Platelets, 1,000/cc3 | 254±4.1 | 289±4.1 | <0.01 | 264±3.7 | 288±4.9 | <0.01 |
| Serum Glucose, mg/dl | 94.3±0.8 | 89.6±0.7 | <0.01 | 92.3±0.7 | 90.8±0.9 | 0.19 |
| Insulin, IU | 9.56±0.63 | 8.86±0.53 | 00.39 | 8.58±0.41 | 9.96±0.78 | 0.09 |
| HOMA | 2.36±0.19 | 2.08±0.16 | 00.27 | 2.04±0.12 | 2.43±0.24 | 0.12 |
| Plasma renin activity, ng/dl/min | 1.13±0.09 | 0.88±0.07 | <0.01 | 1.28±0.09 | 0.58±0.04 | <0.01 |
| HDL, mg/dl | 45.3±0.9 | 53.4±0.8 | <0.01 | 48.9±0.8 | 51.4±1.0 | 0.06 |
| LDL, mg/dl | 120.7±2.2 | 119.7±1.8 | 0.73 | 118.0±1.7 | 123.1±2.4 | 0.07 |
| Total cholesterol, mg/dl | 194.5±2.5 | 195.1±2.1 | 0.85 | 194.9±2.0 | 194.7±2.7 | 0.96 |
| Serum triglycerides, mg/dLl | 142.1±7.6 | 109.5±4.4 | <0.01 | 139.6±5.5 | 101.2±6.1 | <0.01 |
Data are mean +/- SE unless otherwise noted. Bolded values indicate P values <0.05.
Abbreviations: eGFR, estimated glomerular filatration rate; HDL, high-density lipoprotein; HOMA, homeostasis model assessment; LDL, low-density lipoprotein; WBC, white blood cell.