(A) ARs mRNA expression in the aorta from C57BL/6 (C57) and APOE-KO fed an HFD (APOE-HFD) by real-time RT–PCR; (B) A1 AR western blot and densitometry analysis of aortas from C57BL/6 (C57), APOE-KO (APOE), and APOE-KO fed an HFD (APOE-HFD); (C) PCNA western blot and densitometry analysis of aortas from C57, APOE-HFD, and DKO fed an HFD (DKO-HFD). Data are expressed as mean ± SEM. *Significant difference from C57. #Significant difference from APOE in B, from APOE-HFD in C. P < 0.05.