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. 2014 Mar 19;5:113. doi: 10.3389/fimmu.2014.00113

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Copyright © 2014 Ratliff, Templeton, Ward and Webb.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bright expression during B lymphopoiesis. Gray cells indicate B lineage subsets not known to express Bright. Purple subsets express Bright, while lighter shades (T2, MZ B, and B1 B) represent slightly lower levels of Bright expression. Bright is required for development of B1 B cells indicated by red hash marks. Bolded arrow indicates developmental skewing caused by Bright over-expression. CLP, common lymphoid progenitor; MZ B, marginal zone B cells; FO B, follicular B cell; GC B, germinal center B cells.