Figure 4.

Individual V_H gene segment usage in Igμ and Igγ transcripts from selected B cell populations in the blood of a normal, healthy human. Percent of unique, in-frame sequences using the individual V_H gene segments specified in the peripheral blood from immature, transitional, mature, memory IgD⁺, memory IgD⁻ B cells, and plasmacytes are displayed. All comparisons were made using χ²-test or Fisher’s exact test as appropriate. Significant differences among each fraction in the different mice are indicated by asterisks: *p ≤ 0.01, **p ≤ 0.001, ***p ≤ 0.0001.