Table 2.

Expression of proteins in different tissues of O. melastigma under various environmental stresses.

Related functions	Proteins	Expression tissues and exposure condition	References
Cell structure	Histone-binding protein RBBP4	Gill (Br)	[36]
	Gelsolin	Gill, brain (Br)	[36]
	Krt4 protein	Gill (Br)	[36]
Oxidative stress response	Hemoglobin beta chain	Gill (Br)	[36]
	Histone H3	Gill (Br)	[36]
	Glial fibrillary acidic protein	Brain (Br)	[36]
	Keratin 15 [KRT15]	Brain (Br), liver (Hg)	[36, 37]
	Zgc: 65851	Brain (Br)	[36]
	Type I cytokeratin, enveloping layer [CYT1]	Brain (Br), liver (Hg)	[36, 37]
	Myosin light chain 2	Brain (Br)	[36]
	Tropomyosin alpha-3 chain	Brain (Br)	[36]
	α-Tubulin 1	Liver (Hg)	[37]
	Keratin 8	Liver (Hg)	[37]
	α-Actin	Liver (Hg)	[37]
	Keratin 18	Liver, brain (Hg)	[37]
	β-Actin	Liver, brain (Hg)	[37]
	Type I keratin-like protein	Liver (Hg)	[37]
	Lamin type B	Liver (Hg)	[37]
	Krt5 protein	Brain (Hg)	[37]
	Type II basic cytokeratin	Brain (Hg)	[37]
	Keratin K10 [KRT10]	Liver (Hg)	[38]
	Novel protein similar to vertebrate plectin 1 [PLEC]	Liver (Hg)	[38]
	Peroxiredoxin 4	Liver (Hg)	[38]
	Peroxiredoxin 6	Liver (Hg)	[38]
	Glutathione S-transferase [GSTR]	Liver (Hg)	[38]
	SOD [Cu-Zn]	Liver (Hg)	[38]
	Aldehyde dehydrogenase 1 family, member A2	Brain (Hg)	[38]
	Aldehyde dehydrogenase, mitochondrial	Brain (Hg)	[38]
	Peroxiredoxin-2 [PRDX2]	Liver (Hg)	[38]
	Natural killer enhancing factor	Liver (Hg)	[37]
	Peroxiredoxin-1 [PRDX1]	Liver (Hg)	[38]
	DJ-1 protein [DJ-1]	Liver (Hg)	[38]
	Cathepsin D [CTSD]	Liver (Hg)	[38]
	proliferating cell nuclear antigen [PCNA]	Testis, muscle, kidney, liver Cheek, brain, intestine, and ovary embryo during each development period (H)	[16, 39]
	Telomerase Reverse Transcriptase [TERT]	Testis, brain, muscle, gill, intestine, kidney (N), and liver (H)	[16]
	superoxide dismutase [SOD]	Whole fish (Z)	[40]
	Metallothionein [MT]	Whole fish (Z)	[40]
	heat shock protein 70 [HSP70]	Whole fish (Z)	[40]
Metabolism	ApoA-IV4	Gill (Br)	[36]
	Aldose reductase	Gill, brain (Br)	[36]
	Pyruvate carboxylase	Brain (Br)	[36]
	Dpysl5a protein	Brain (Br)	[36]
	Triosephosphate isomerase	Brain (Br)	[36]
	Enolase	Brain (Br)	[36]
	Glutamine synthetase	Brain (Br, Hg)	[36, 37]
	Isovaleryl coenzyme A dehydrogenase	Brain (Br)	[36]
	Glyceraldehyde 3-phosphate dehydrogenase	Brain (Br)	[36]
	Homogentisate 1,2-dioxygenase	Liver (Hg)	[37]
	Alanyl-tRNA synthetase, cytoplasmic	Liver (Hg)	[37]
	Dihydrolipoamide S-acetyltransferase	Liver (Hg)	[37]
	Adenosylhomocysteinase	Liver (Hg)	[37]
	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial	Liver (Hg)	[37]
	Brain-type fatty acid binding protein	Liver (Hg)	[37]
	Methionine adenosyltransferase-like	Liver (Hg)	[37]
	S-formylglutathione hydrolase	Liver (Hg)	[37]
	Apolipoprotein A1	Brain (Hg)	[37]
	Pyruvate kinase	Brain (Hg)	[37]
	Dihydropyrimidinase-related protein 5	Brain (Hg)	[37]
	Dihydropyrimidinase-like 2	Brain (Hg)	[37]
	Enolase 1, (alpha)	Brain (Hg)	[37]
	Creatine kinase, brain b	Brain (Hg)	[37]
	Total glutathione [GSH]	Whole fish (W)	[25]
	Glutathione S-transferase [GST]	Whole fish (W)	[25]
	Sulfotransferase [SULT]	Whole fish (W)	[25]
	Superoxide dismutase [SOD]	Whole fish (W)	[25]
	Glutathione reductase [GR]	Whole fish (W)	[25]
	Glutathione peroxidase [GPx]	Whole fish (W)	[25]
	Catalase, CAT	Whole fish (W)	[25]
	ATP synthase subunit d, mitochondrial [ATP5H]	Liver (Hg)	[38]
	Electron-transferring-flavoprotein dehydrogenase [ETFDH]	Liver (Hg)	[38]
	Electron transferring flavoprotein subunit alpha, mitochondrial [ETFA]	Liver (Hg)	[38]
	Pyruvate dehydrogenase (lipoamide) beta [PDHB]	Liver (Hg)	[38]
	Phytanoyl-CoA dioxygenase domain-containing protein 1 [PHYD1]	Liver (Hg)	[38]
	Delta3,5-delta2,4-dienoyl-CoA isomerase, mitochondrial [ECH1]	Liver (Hg)	[38]
	Phosphorylase [PYGB]	Liver (Hg)	[38]
	Formimidoyltransferase-cyclodeaminase [FTCD]	Liver (Hg)	[38]
Signal transduction	Putative transient receptor protein 2	Gill (Br)	[36]
	Myosin regulatory light chain 2	Gill (Br)	[36]
	FXYD domain-containing ion transport regulator	Gill (S)	[5]
	NKCC1a-like protein	Gill (S)	[32]
	NKA α-subunit	Gill (S)	[7, 32]
	Grancalcin	Gill (Br)	[36]
Protein modification	Myosin light chain 2	Gill (Br)	[36]
	Calreticulin, like 2	Gill (Br)	[36]
	Transforming protein RhoA	Brain (Br, Hg)	[36, 37]
	Calmodulin	Brain (Br)	[36]
	Annexin 4	Liver (Hg)	[37]
	14-3-3E1 protein	Liver (Hg)	[37]
	14-3-3 protein	Liver (Hg)	[37]
	Annexin A13	Brain (Hg)	[37]
	Cytosolic nonspecific dipeptidase	Liver (Hg)	[37]
	Proteasome alpha 1 subunit	Liver (Hg)	[37]
	HSP-90	Brain (Hg)	[37]
Other function related	Chaperonin containing TCP1, subunit 8 (theta)	Brain (Hg)	[37]
	Beta-synuclein	Brain (Br)	[36]
	SH3-domain GRB2-like endophilin B2	Brain (Br)	[36]
	Complement component C3-1	Liver (Hg)	[37]
	Carbonic anhydrase 1	Brain (Hg)	[37]
	ATPase, H+ transporting, V0 subunit D isoform 1	Brain (Hg)	[37]
	Transferrin	Brain (Hg)	[37]
	Eukaryotic translation initiation factor 3, subunit 2 beta [EIF3S2]	Liver (Hg)	[38]
	Histone H4	Liver (Hg)	[38]
	Ependymin [EPD]	Liver (Hg)	[38]
	GammaN1 crystallin [CRYGN1]	Liver (Hg)	[38]

Notes: the abbreviations in parentheses mean the protein expression in the environment of exposure to normal (N), hypoxia (H), brevetoxins (Br), HgCl₂ (Hg), salinity (S), nZnO (Z), and WAFs of Iranian crude oil (W).