Table 5.
Multivariate logistic regression analysis for identification of independent clinical factors and biomarkers of predicting ICU mortality.
| Variable | Adjusted odds ratio | 95% Confidence interval | P |
|---|---|---|---|
| Clinical factors for predicting ICU mortality | |||
| Age | 1.506 | 0.807–2.810 | 0.198 |
| Initial appropriate antibiotics use | 0.032 | 0.001–0.814 | 0.037 |
| APACHE II score | |||
| Day 1 | 0.001 | <0.001–90.210 | 0.239 |
| Day 3 | 1024.53 | 0.009–1.187 | 0.244 |
| Day 3 : day 1 | 8.566 | 0.003–27664.475 | 0.602 |
| SOFA score | |||
| Day 1 | 0.032 | <0.001–34.761 | 0.335 |
| Day 3 | 2.756 | 0.711–10.687 | 0.143 |
| SAPS II score | |||
| Day 1 | 2.222 | 0.111–44.423 | 0.601 |
| Day 3 | 0.558 | 0.030–10.234 | 0.694 |
| Day 3 : Day 1 | 0.469 | <0.001–28252.867 | 0.893 |
|
| |||
| Biomarkers for predicting ICU mortality | |||
| CRP (mg/L) day 3 | 1.265 | 0.798–2.005 | 0.317 |
| D-dimer (ng/mL) day 1 | 1.211 | 0.818–1.793 | 0.339 |
| Lactate (mg/dL) ratio | 0.879 | 0.005–163.371 | 0.879 |
| Albumin (g/dL) day 3 | 1.075 | <0.001–7.976 | 0.261 |
| HMGB1 (pg/mL) | |||
| Day 1 | 1.002 | 1.000–1.004 | 0.026 |
| Day 3 | 0.990 | 0.968–1.013 | 0.384 |
| IL8 (pg/mL) | |||
| Day 1 | 1.039 | 0.955–1.130 | 0.737 |
| Day 3 | 1.075 | 0.940–1.229 | 0.291 |
aICU: intensive care unit; APACHE II: Acute Physiology and Chronic Health Evaluation II; SOFA: Sequential Organ Failure Assessment; SAPS II: Simplified Acute Physiology Score II; CRP: C-reactive protein; HMGB1: high-mobility group protein B1; and IL: interleukin.