Figure 2.

Relationship between Testosterone and magnesium, potential underlying mechanisms and clinical implications. The aging process is frequently characterized by an impaired homeostatic reserve due to an imbalance between energy assumption (left side) and utilization and consumption (middle and right sides). The activity of anabolic hormones, where T plays a central role, is influenced by mineral status (magnesium), along with caloric and protein intake. The systemic inflammation, which negatively influences magnesium and T and is in turn downregulated by these 2 factors.